| Identification | Back Directory | [Name]
BA, 3NH4 | [CAS]
1177154-51-6 | [Synonyms]
BA, 3NH4
BONGKREKIC ACID, TRIAMMONIUM SALT
3-CARBOXYMETHYL-17-METHOXY-6,18,21-TRIMETHYLDOCOSA-2,4,8,12,18,20-HEPTAENEDIOIC ACID
2,4,8,10,14,18,20-Docosaheptaenedioic acid, 20-[2-(aminooxy)-2-oxoethyl]-6-methoxy-2,5,17-trimethyl-, 1,22-diazanyl ester, (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)- | [Molecular Formula]
C28H47N3O7 | [MDL Number]
MFCD02179190 | [MOL File]
1177154-51-6.mol | [Molecular Weight]
537.69 |
| Hazard Information | Back Directory | [Uses]
Bongkrekic acid is an inhibitory ligand of the mitochondrial adenine nucleotide translocase. It inhibits mitochondrial permeability transition pore opening. At 50 μM it inhibits dexamethasone- apoptosis in thymocytes, preventing the PARP cleavage and DEVDase (caspase-3 like) activity normally produced by these treatments. | [Biological Activity]
Bongkrekic acid is an inhibitory ligand of the mitochondrial adenine nucleotide translocase. It inhibits mitochondrial permeability transition pore opening. At 50 μM it inhibits dexamethasone- apoptosis in thymocytes, preventing the PARP cleavage and DEVDase (caspase-3 like) activity normally produced by these treatments. |
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