| Identification | Back Directory | [Name]
Citicoline sodium | [CAS]
33818-15-4 | [Synonyms]
Logan
Sinkron
Cidifos
Gerolin
Brassel
Cebroton
5′-CDP,Na
Acticolin
Neurotron
Flussorex
CITICOLINE
CDP-COLINE
Cytidine-5'-
IP 302 SodiuM
Citicoline sod
CDP-CHOLINE, NA
CITICOLINE SODIUM
CDP-CHOLINE, SODIUM
Citicoline SodiuM API
CITICOLINE SODIUM SALT
CDP-CHOLINE, SODIUM SALT
CITICOLINE MONOSODIUM SALT
CDP-CHOLINE MONOSODIUM SALT
Citicoline Sodium, Vetranal
Citicoline sodiuM salt hydrate
CYTIDINE-5'-DIPHOSPHOCHOLINE, NA
CDPC (Citicoline MonosodiuM salt)
CYTIDINE-5'-DIPHOSPHOCHOLINE, SODIUM
Cdp-Choline(CytidineDiphosphateCholine)
CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT
CYTIDINE-5'-DIPHOSPHOCHOLINE MONOSODIUM SALT
cytidin-5'-diphosphocholin sodium salt hydrate
Cytidine 5′-diphosphocholine sodium salt hydrate
CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE
Cytidine 5μ-diphosphocholine dihydrate sodium salt
Cytidine 5'-Diphosphocholine Sodium Salt CDP-choline.Na
CITICOLINE SODIUM (CDP-COLINE/ CITIDINE (5I)-DIPHOSPHOCHOLINE)
Cytidine 5'-diphosphoric acid α-sodium β-[2-(trimethylammonio)ethyl] ester salt
P'-[2-(TRIMETHYLAMMONIO)ETHYL]ESTER CYTIDINE 5'-(TRIHYDROGEN DIPHOSPHATE) INNER SALT MONOSODIUM
Cytidine 5'-(Trihydrogen Diphosphate) P'-[2-(TriMethylaMMonio)ethyl] Ester Inner Salt SodiuM Salt
cytidine 5'-(trihydrogen diphosphate) p'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt
Cytidine 5'-(trihydrogen diphosphate) P'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt
Cytidine5'-(trihydrogen diphosphate), P'-[2-(triMethylaMMonio)ethyl] ester, inner salt,sodiuM salt (1:1)
Cytidine 5'-(trihydrogen diphosphate), mono[2-(trimethylammonio)ethyl] ester, hydroxide, inner salt, monosodium salt
CDP-choline-Na, CDP-coline, Citicoline sodium, Pμ-[2-(Trimethylammonio)ethyl]ester cytidine 5μ-(trihydrogen diphosphate) inner salt monosodium
Cytidine 5′-diphosphocholine sodium salt dihydrate,CDP-choline-Na, CDP-coline, Citicoline sodium, P′-[2-(Trimethylammonio)-ethyl]-ester cytidine 5′-(tri-hydro-gen di-phos-phate) inner salt monosodium
CDP-choline-Na, CDP-coline, Citicoline sodium, Cytidine 5μ-diphosphocholine dihydrate sodium salt, Pμ-[2-(Trimethylammonio)ethyl]ester cytidine 5μ-(trihydrogen diphosphate) inner salt monosodium | [EINECS(EC#)]
251-689-1 | [Molecular Formula]
C14H25N4NaO11P2 | [MDL Number]
MFCD00037486 | [MOL File]
33818-15-4.mol | [Molecular Weight]
510.31 |
| Chemical Properties | Back Directory | [Melting point ]
259-268°C (dec.) | [alpha ]
D20 +12.5° (c = 1.0 in H2O) | [storage temp. ]
2-8°C
| [solubility ]
H2O: 100mg/mL
| [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble in water (100 mg/ml). | [λmax]
280nm(HCl aq.)(lit.) | [Merck ]
13,2343 | [BRN ]
4110040 | [InChIKey]
YWAFNFGRBBBSPD-OCMLZEEQSA-M | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O.[NaH] |&1:1,2,3,21,r| | [CAS DataBase Reference]
33818-15-4 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Usage]
Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. | [Uses]
Cytidine 5′-diphosphate (CDP) is used as a substrate of CDP (nucleoside diphosphate) kinase (2.7.4.6) to produce CTP in support ofDNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP. | [Uses]
Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. | [Brand name]
CerAxon (Interneuron). | [General Description]
Cytidine 5′-diphosphocholine (CDP-choline) contains cytidine and choline linked via a diphosphate bridge. | [Biochem/physiol Actions]
Cytidine 5′-diphosphocholine (CDP-choline) plays an important role in the synthesis of phosphatidylcholine. It is also involved in the biosynthesis of acetylcholine, a neurotransmitter. CDP-choline has therapeutic effects against hypoxia, cerebral ischemia and traumatic brain injury. It also exhibits therapeutic effects against learning and memory disorders, drug addiction and Alzheimer′s and Parkinson′s diseases. | [Side effects]
Citicoline sodium may be safe for 12 weeks of oral use, side effects may include stomach pain, back pain, blurred vision, constipation and headache. While Citicoline 2% Eye Drops may be safe for long-term use (up to 3 years). No serious side effects have been reported by clinical investigators in the treatment of Parkinson's disease. | [Safety]
There are two forms of citicoline: citicoline sodium and citicoline free-base. Citicoline sodium is the form that is approved as a prescription medication in some European countries and throughout Asia. Citicoline free-base is the form that is available as a dietary supplement and food/beverage ingredient in the United States. In Europe, citicoline is approved as a Novel Food ingredient and is authorized to be used in food supplements up to 500 mg per day. It is also authorized to be used for Food for Special Medical Purposes (FSMPs) in amounts of 250 mg/serving and up to 1,000 mg per day.
Citicoline free-base is produced in Japan by Kyowa Hakko Bio Co. Ltd. under the brand name of Cognizin. Cognizin is considered to be safe and received self-designated Generally Recognized As Safe (GRAS) status in 2009. In Europe, citicoline was approved as a Novel Food ingredient in 2014. Whereas most companies produce citicoline synthetically, Cognizin is produced using a patented, natural fermentation process. It is vegetarian and allergen-free. Kyowa Hakko manufactures and supplies Cognizin as a raw ingredient to many manufacturers around the world. | [Metabolism]
Citicoline can be administered orally, intramuscularly, or intravenously. Oral administration is most common because its bioavailability is approximately 92%. After oral ingestion, citicoline is hydrolyzed in the small intestine and liver into 2 major metabolites: cytidine and choline.
Cytidine and choline enter the systemic circulation, where cytidine is further metabolized into uridine. Both uridine and free choline cross the blood-brain barrier. In the central nervous system, uridine is converted to cytidine triphosphate, choline is converted to phosphocholine, and the 2 combine to resynthesize CDP-choline. | [storage]
Store at -20°C |
| Questions And Answer | Back Directory | [Description]
Citicoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956. Kennedy study confirmed that citicoline can make brain injury recovery in 1957. Takeda pharmaceutical company in Japan developed and produced it in 1961. It was registered in China in 1988, and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects.
| [Application]
- Central nervous system medication.
- Coenzyme. For acute traumatic brain injury and brain surgery consciousness. Acute brain injury and brain surgery after a disturbance of consciousness, paralysis due to stroke can gradually restore the function of the limbs, it can also be used for functions and other central nervous system disorders of consciousness caused by acute injury, and also for ischemic cerebrovascular disease and vascular dementia.
| [Mechanism of action]
Citicoline sodium can enhance the function of brain stem reticular formation, especially the ascending reticular activating system associated with human consciousness; enhance the function of the pyramidal system; inhibit the function of the external system of the cone, and promotes the recovery of the function of the system. For the treatment of sequelae of traumatic brain injury and cerebral vascular accident caused by the nervous system, it can also be used in the treatment of Parkinson's disease, senile dementia has a certain effect; for the treatment of cardiovascular and cerebrovascular diseases; it also have a certain effect for anti-aging, improving learning and memory. |
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