| Identification | More | [Name]
Mebeverine hydrochloride | [CAS]
2753-45-9 | [Synonyms]
COLOFAC
MEBEVERINE
MEBEVERINE HCL
MEBEVERINE HYDROCHLORIDE
4-(ethyl(p-methoxy-alpha-methylphenethyl)amino)butylveratratehydrochloride
csag-144
duspatalin
veratricacid,4-(ethyl(p-methoxy-alpha-methylphenethyl)amino)butylester,hydr
3,4-Dimethoxybenzoicacid4-ethyl2-(4-methoxyphenyl)-1-methylethylaminobutylesterhydrochloride
4-[Ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate hydrochloride | [EINECS(EC#)]
220-400-0 | [Molecular Formula]
C25H35NO5 | [MDL Number]
MFCD00867721 | [Molecular Weight]
429.55 | [MOL File]
2753-45-9.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
YX5425000
|
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Duspatalin,Duphar,France,1965 | [Uses]
muscarinic ACh agonist, antiglaucoma | [Uses]
Smooth muscle relaxant. Antispasmodic. | [Manufacturing Process]
(A) Sodium-3,4-Dimethoxybenzoate: A solution of 91 g of 3,4- dimethoxybenzoic acid in 500 ml of boiling, absolute alcohol was added quickly to a solution of 11.5 g of sodium in 300 ml of absolute alcohol; after cooling to room temperature the resulting precipitate was filtered off and washed with 2 x 50 ml of absolute alcohol and 4 x 200 ml of ether and dried in air to constant weight; yield 92.5 g, MP about 265°C. The filtrate was bulked with the alcohol and ether washings, left to stand overnight, and a further precipitate then filtered off, washed with 3 x 100 ml of ether, and dried in air to constant weight. Yield 22.5 g, MP about 265°C. Total yield therefore 115 g (=113%).
(B) 4'-Chlorobutyl-3,4-Dimethoxybenzoate: 92 g of the sodium salt described
under (A) (it contains at the most 81.5 g of sodium 3,4-dimethoxybenzoate)
was boiled in 900 ml of tetramethylene dichloride for 90 hours; after cooling
the mixture was filtered and the residue washed with 3 x 50 ml of ether. The
filtrate was evaporated to dryness in vacuo and the residue (102 g) was
distilled in vacuo. Fraction 1: 50° to 55°C/0.5 mm; 19 g (probably
tetramethylene dichloride). Fraction 2: 175° to 184°C/0.5 mm; 77.5 g
(=71%); Cl= 12.6% (calculated 13.0%). Remark: The second fraction
partially solidified or became more viscous on standing, and even during the
distillation.
(C) 4'-Iodobutyl-3,4-Dimethoxybenzoate: 32.5 g of 4'-chlorobutyl-3,4-
dimethoxybenzoate and 19.5 g of sodium iodide (10% excess) were boiled in
150 ml of methyl ethyl ketone for 2.5 hours; after cooling and filtering off the
sodium chloride produced, the reaction was found not to be entirely
completed; boiling was then continued for another two hours; the reaction
mixture was cooled, and the solid filtered off and washed with 2 x 100 ml of
ether.
The filtrate was evaporated to dryness in vacuo and the residue was dissolved
in 300 ml of ether and 100 ml of water; the layers were separated and the
water layer was once again extracted with 100 ml of ether; then the ether
layers were boiled and washed again with a solution of 3.5 g of sodium
thiosulfate in 100 ml of water. The ether layer was dried over sodium sulfate.
Finally the solution was filtered and the ether was evaporated; the residue
was an almost colorless oil, which partially solidified or became more viscous
after being left to stand for some time. Yield: 40 g (=92%), I=34.2%
(calculated 34.9%).
(D) 4'-[N-Ethyl-1''-Methyl-2''-(4'''-Methoxyphenyl)Ethylamino]Butyl-3,4-
Dimethoxybenzoate Hydrochloride: 10.3 g of 4'-iodobutyl-3,4-
dimethoxybenzoate and 11.0 g of N-ethyl-p-methoxyphenylisopropylamine
(obtained by catalytic reduction of an alcoholic solution of an excess quantity
(60%) of p-methoxy-phenyl-acetone, to which was added a 33% (weight-for-weight) aqueous solution of ethylamine, with Pt as a catalyst), were boiled in
200 ml of methyl ethyl ketone for 20 hours, cooled and the iodine ion was
determined; the reaction was found to be complete. Then the methyl ethyl
ketone was evaporated in vacuo and the residue was dissolved in 300 ml of
water and 30 ml of ether; the layers were separated and the water layer was
extracted twice more with 20 ml portions of ether. | [Therapeutic Function]
Spasmolytic | [storage]
Store at -20°C |
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