| Identification | More | [Name]
Boc-5-aminopentanoic acid | [CAS]
27219-07-4 | [Synonyms]
5-(BOC-AMINO)PENTANOIC ACID
5-(BOC-AMINO)VALERIC ACID
5-(TERT-BUTOXYCARBONYLAMINO)PENTANOIC ACID
5-(TERT-BUTOXYCARBONYLAMINO)VALERIC ACID
BOC-5-AMINOPENTANOIC ACID
BOC-5-AMINOVALERIC ACID
BOC-5-AVA-OH
BOC-APE(5)-OH
BOC-DELTA-AMINOVALERIC ACID
BOC-NH-(CH2)4-COOH
N-BOC-5-AMINOPENTANOIC ACID
N-BOC-5-AMINOVALERIC ACID
N-DELTA-T-BUTOXYCARBONYL-DELTA-AMINOVALERIC ACID
N-T-BUTOXYCARBONYL-5-AMINOPENTANOIC ACID
PENTANOIC ACID, 5-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-
RARECHEM EM WB 0073
5-(Boc-amino)pentanoic acid, 5-(Boc-amino)valeric acid
5-[(tert-Butyloxycarbonyl)amino]pentanoic acid
5-[[(1,1-Dimethylethyl)oxy]carbonyl]aminopentanoic acid | [Molecular Formula]
C10H19NO4 | [MDL Number]
MFCD00076903 | [Molecular Weight]
217.26 | [MOL File]
27219-07-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
48-52 °C(lit.) | [Boiling point ]
160-168 °C0.8 mm Hg(lit.) | [density ]
1.1518 (rough estimate) | [refractive index ]
1.4500 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
soluble in Methanol | [form ]
Powder | [pka]
4.72±0.10(Predicted) | [color ]
Off-white | [BRN ]
2048862 | [CAS DataBase Reference]
27219-07-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10-21 | [HazardClass ]
IRRITANT | [HS Code ]
29241990 |
| Hazard Information | Back Directory | [Description]
Boc-5-aminopentanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. Boc-5-aminopentanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Chemical Properties]
solid | [Uses]
Boc-5-aminovaleric acid can be used to synthesize inhibitors of bacterial quorum seining and biofilm formation. It can also be used to synthesize diblock and triblock copolymers. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 48, p. 2424, 1983 DOI: 10.1021/jo00162a028 |
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