| Identification | More | [Name]
4,4'-DIPYRIDYL DISULFIDE | [CAS]
2645-22-9 | [Synonyms]
4,4'-DIPYRIDYL DISULFIDE
4,4'-DIPYRIDYL DISULPHIDE
4,4'-DITHIODIPYRIDINE
ALDRITHIOL(TM)-4
DTDP
4-(4-Pyridinyldisulfanyl)pyridine
4,4'-Dipyridine disulfide
4,4'-Dithiopyridine
4-Pyridyl disulfide
Aldrithiol 4
Aldrithol-4
Bis(4-pyridyl) disulfide
Di(4-pyridyl) disulfide
Pyridine, 4,4'-dithiodi-
Aldrithiol™
-4
4-Pds
4,4Dipyridyldisulfide-(4,4dithiodipyridine)
4,4'-Dipyridyldisulfide,98%
4,4''-DIPYRIDYL DISULFIDE 97+%
1,2-DI(PYRIDIN-4-YL)DISULFANE | [EINECS(EC#)]
220-158-6 | [Molecular Formula]
C10H8N2S2 | [MDL Number]
MFCD00006423 | [Molecular Weight]
220.31 | [MOL File]
2645-22-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white to orange crystalline powder | [Melting point ]
76-78 °C(lit.) | [Boiling point ]
356.1±17.0 °C(Predicted) | [density ]
1.3078 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
0-6°C | [solubility ]
95% ethanol: soluble5%, clear, colorless to light yellow | [form ]
Crystalline Powder | [pka]
3.60±0.26(Predicted) | [color ]
White to orange | [BRN ]
154742 | [InChIKey]
UHBAPGWWRFVTFS-UHFFFAOYSA-N | [CAS DataBase Reference]
2645-22-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyridine, 4,4'-dithiobis-(2645-22-9) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to orange crystalline powder | [Uses]
- Aldrithiol?-4 was used as cosubstrate in a study to develop highly specific inhibitors against mannose-binding lectin-associated serine proteases by in vitro evolution technology:phage display.
- It was used to study the O2 equilibria of recombinant human neuroglobin and cytoglobin measured under close to physiological conditions.
- It was used to modify gold surfaces for protein studies.
| [Definition]
ChEBI: An organic disulfide obtained by formal oxidative dimerisation of 4-thiopyridine. | [Purification Methods]
Recrystallise the disulfide from H2O, EtOH, Me2CO, *C6H6 or pet ether. It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 4-mercaptopyridine (4-pyridinethiol) anion, thereby shifting the max from 324nm (of the disulfide) to 285nm (of the anion) at pH 9. (Compare with 2,2’dipyridyl disulfide above which has been used for the same purpose.) [Humphrey et al. Anal Chem 40 698 1970, Cheng & Ritchie Aust J Chem 26 1785 1973.] [Beilstein 21 II 35, for review see Aldrichimica Acta 4 33 1971.] |
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