| Identification | More | [Name]
S-Methyl methanethiolsulfonate | [CAS]
2949-92-0 | [Synonyms]
METHANETHIOSULFONIC ACID S-METHYL ESTER
METHYL METHANETHIOLSULFONATE
METHYL METHANETHIOSULFONATE
MMTS
S-METHYL METHANETHIOLSULFONATE
S-METHYL METHANETHIONSULFONATE
S-METHYL METHANETHIOSULFONATE
S-METHYL METHANETHIOSULPHONATE
S-METHYL THIOMETHANESULFONATE
dimethyl thiosulfonate
Methanesulfonic acid, thio-, S-methyl ester
Methanesulfonothioic acid, S-methyl ester
methanesulfonothioicacid,s-methylester
Methyl methanesulfonothioate
methylmethanesulfonothioate
S-Methyl methanesulfonothioate
S-methyl methylthiosulfonate
s-methylmethanesulfonothioate
thio-methanesulfonicacis-methylester
S-Methyl thiomethanesuphonate | [EINECS(EC#)]
220-970-0 | [Molecular Formula]
C2H6O2S2 | [MDL Number]
MFCD00007565 | [Molecular Weight]
126.2 | [MOL File]
2949-92-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow Liquid | [Melting point ]
117.0-119.0 °C | [Boiling point ]
69-71 °C0.4 mm Hg(lit.)
| [density ]
1.337 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.513(lit.)
| [Fp ]
190 °F
| [storage temp. ]
2-8°C
| [solubility ]
chloroform: soluble750mg + 5 ml Chloroformmg/mL, colorless to light greenish-yellow | [form ]
clear liquid | [color ]
Colorless to Red to Green | [Odor]
at 0.10 % in propylene glycol. sulfurous pungent roasted | [Odor Type]
sulfurous | [Usage]
Used for the rapid and selective modification of sulfhydryl groups of enzymes. Useful for mapping the pore-lining regions of the ryanodine receptor.
| [BRN ]
1446059 | [Stability:]
Water Sensitive | [InChIKey]
XYONNSVDNIRXKZ-UHFFFAOYSA-N | [LogP]
0.247 (est) | [CAS DataBase Reference]
2949-92-0(CAS DataBase Reference) | [NIST Chemistry Reference]
S-methyl methanethiosulphonate(2949-92-0) | [EPA Substance Registry System]
2949-92-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36:Irritating to the eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3334 | [WGK Germany ]
2
| [RTECS ]
PB2765000
| [F ]
13 | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29309090 | [Toxicity]
mouse,LD50,intraperitoneal,9110ug/kg (9.11mg/kg),Toxicology and Applied Pharmacology. Vol. 72, Pg. 513, 1984. |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Liquid | [Uses]
S-Methyl methanethiosulfonate was used as sulfenylating agent for β-keto sulfoxides, methylene compounds, half-esters of malonic acids and aryl Grignard reagents. It was also used as a reagent to trap the natural thiol-disulfide state of the proteins. | [Uses]
carbonyl reactive homobifunctional cross-linking reagent cleavable with periodate | [Uses]
S-Methyl methanethiolsulfonate is used for the rapid and selective modification of sulfhydryl groups of enzymes and it is also useful for mapping the pore-lining regions of the ryanodine receptor.
| [Definition]
ChEBI: A sulfonic acid derivative obtained by condensaton of methanesulfonic acid with methanethiol. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 49, p. 2281, 1984 DOI: 10.1021/jo00186a039
Synthetic Communications, 20, p. 365, 1990 DOI: 10.1080/00397919008052777 | [General Description]
Interaction of S-methyl methanethiosulfonate (MMTS) with dipalmitoylphosphatidylcholine (DPPC) bilayers has been investigated by FTIR and surface-enhanced Raman spectroscopy. | [Purification Methods]
Purify it by fractional distillation under reduced pressure, IR: 1350, 750 cm-1 . [Applegate et al. J Org Chem 38 943 1973, Beilstein 4 IV 31.] |
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