Identification | More | [Name]
4-Aminopyrazolo[3,4-d]pyrimidine | [CAS]
2380-63-4 | [Synonyms]
1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE 4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE ADENINE ANTIMETABOLITE TIMTEC-BB SBB004205 1H-Pyrazolo[3,4-d]pyrimidine, 4-amino- 4 APP 4-Aminopyrazole(3,4-d)pyrimidine 4-Aminopyrazolopyrimidine 4-app 4-d)pyrimidine,4-amino-1h-pyrazolo( NSC 1393 nsc1393 Pyrazoloadenine 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI) Adenine antimetabolite, Pyrazolo[3,4-d]pyrimidin-4-amin Aminopurinol 4-Amino-1,2,5,7-tetraaza-1H-indene | [EINECS(EC#)]
219-174-6 | [Molecular Formula]
C5H5N5 | [MDL Number]
MFCD00005688 | [Molecular Weight]
135.13 | [MOL File]
2380-63-4.mol |
Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S22:Do not breathe dust . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
UR0717000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29335990 | [Toxicity]
LD50 oral in rat: 141mg/kg |
Hazard Information | Back Directory | [Description]
4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2]. | [Chemical Properties]
Light Tan Solid | [Uses]
4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats. | [References]
[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8. [2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.
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