成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->2230077-10-6

2230077-10-6

2230077-10-6 Structure

2230077-10-6 Structure
IdentificationBack Directory
[Name]

MS4077
[CAS]

2230077-10-6
[Synonyms]

MS4077
1-Piperidineacetamide, 4-[4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-N-[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]-
[Molecular Formula]

C55H72ClN9O13S
[MDL Number]

MFCD31812631
[MOL File]

2230077-10-6.mol
[Molecular Weight]

1134.73
Chemical PropertiesBack Directory
[density ]

1.318±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C, sealed storage, away from moisture and light
[solubility ]

DMSO : 110 mg/mL (96.94 mM; Need ultrasonic)
[form ]

Solid
[pka]

10.74±0.40(Predicted)
[color ]

Yellow to green
Hazard InformationBack Directory
[Biological Activity]

MS4077 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 37 nM for binding affinity to ALK[1]. MS4077 effectively inhibits cancer cell proliferation. MS4077 (10-3-1 μM; 3 days) concentration-dependently inhibits proliferation of SU-DHL-1 cells with an IC50 of 46 ± 4 nM. In comparison with SU-DHL-1 cells, the proliferation of NCI-H2228 cells is less sensitive to MS4077(10-2-100.5 μM; 3 days)[1].MS4077 potently reduces the ALK fusion protein levels and inhibits the ALK auto-phosphorylation and down-steam STAT3 phosphorylation in both SU-DHL-1 and NCI-H2228 cells in a concentration-dependent manner. In SU-DHL-1 cells, MS4077 reduces the NPM-ALK protein levels with impressive DC50 (50% degradation) value of 3±1 nM after 16-hour treatment. Over 90% of inhibition of both ALK Y1507 and STAT3 Y705 phosphorylation is achieved at the 100 nM concentration. In NCI-H2228 cells, MS4077 reduces the EML4-ALK protein levels with similar DC50 value of 34±9 nM after 16-hour treatment. At the 100 nM concentration, NCI-H2228 cells reduces more than 90% of EML4-ALK protein levels[1].
[storage]

Store at -20°C, sealed storage, away from moisture and light
[References]

[1]. Zhang C, et al. Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK). Eur J Med Chem. 2018 May 10;151:304-314.
2230077-10-6 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
Website: https://www.wodapro.com
Company Name: cjbscvictory  
Tel: 13348960310 13348960310
Website: http://www.weikeqi-biotech.com/
Company Name: Changzhou Bojia Biomedical Technology Co., Ltd.  
Tel: 2122619822
Website: www.is0513.com/showsupplierproductslist849747/0.htm
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.  
Tel: 13417589054 13417589054
Website: www.is0513.com/showsupplierproductslist312717/0.htm
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
Tel: 021-59167510 18117107507
Website: www.med-life.cn/
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Website: www.ruidiresearch.com
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 15850508050
Website: http://www.synzest.com
Tags:2230077-10-6 Related Product Information
2229974-83-6 2229036-62-6 2225938-17-8