| Identification | Back Directory | [Name]
MS1943 | [CAS]
2225938-17-8 | [Synonyms]
MS1943
1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one
1H-Indazole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-[2-[(2-tricyclo[3.3.1.13,7]dec-1-ylacetyl)amino]ethyl]-1-piperazinyl]-3-pyridinyl]- | [Molecular Formula]
C42H54N8O3 | [MOL File]
2225938-17-8.mol | [Molecular Weight]
718.93 |
| Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO:100.0(Max Conc. mg/mL);139.1(Max Conc. mM) | [form ]
A solid | [pka]
12.56±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MS1943 is used in the preparation of heterocyclic compounds as EZH2 ligands and their compositions and methods for treating EZH2-mediated cancer. MS1943 itself significantly reduces EZH2 protein levels in numerous triple-negative breast cancer | [Biological Activity]
MS1943 is a potent and selective degrader of EZH2 (enhancer of zeste homolog 2) th at effectively reduces EZH2 levels in cells. MS1943 potently inhibits growth of multiple TNBC cells and in mice xenograft model. |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
|