| Identification | More | [Name]
L-tert-Leucine | [CAS]
20859-02-3 | [Synonyms]
FEMA 3297
H-LEU-OH
H-L-LEU-OH
L-2-AMINO-4-METHYLPENTANOIC ACID
L-2-AMINO-4-METHYLVALERIC ACID
L-A-AMINO-G-METHYL VALERIC ACID
L-A-AMINOISOCAPROIC ACID
LEU
LEUCINE
LEUCINE, L-
L-LEU
L-(-)-LEUCINE
L-LEUCINE
RARECHEM AB PP 3754
(S)-2-AMINO-4-METHYLPENTANOIC ACID
(S)-(+)-LEUCINE
L-α-tert-Butylglycine
L-TERT-LEUCINE, 99% (99% EE/GLC)
L-2-(T-BUTYL)GLYCINE
(2S)-2-Amino-3,3-dimethylbutanoicacid | [EINECS(EC#)]
200-522-0 | [Molecular Formula]
C6H13NO2 | [MDL Number]
MFCD00002617 | [Molecular Weight]
131.17 | [MOL File]
20859-02-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White to almost white powder | [Melting point ]
≥300 °C (lit.) | [alpha ]
6.3 º (c=4, 6 N HCl 200 ºC) | [Boiling point ]
217.7±23.0 °C(Predicted) | [density ]
1.1720 (estimate) | [refractive index ]
-9 ° (C=3, H2O) | [storage temp. ]
Store at RT. | [solubility ]
1 M HCl: 50 mg/mL
| [form ]
powder
| [pka]
2.39±0.12(Predicted) | [color ]
White to almost white | [optical activity]
[α]20/D 9.5°, c = 3 in H2O | [Water Solubility ]
125.5 g/L (20 ºC) | [BRN ]
1721824 | [InChIKey]
NPDBDJFLKKQMCM-SCSAIBSYSA-N | [CAS DataBase Reference]
20859-02-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
OH2850000
| [Hazard Note ]
Irritant | [HS Code ]
29224900 |
| Questions And Answer | Back Directory | [Description]
L-tert-Leucine is an essential amino acid making up one third of our muscle protein. L-tert-leucine is important in developing chiral pharmaceutically active chemicals. It can be used as a food additive. It is used in the formation of sterols. It can also be used as the catalyst in the production of cobalt oxazoline palladacycles complex. It can also be used for the production of Chiral tridentate Schiff base ligands.
| [References]
Korkmaz, Neslihan, D. Astley, and S. T. Astley. "Tridentate ligands derived from L-tert-Leucine for the Cu(II) mediated asymmetric Henry reaction." Turkish Journal of Chemistry 35.3(2011):1-17.
https://www.alfa.com/en/catalog/L13707/
http://igem.org/abstract_pdf_file.cgi?id=1719
[1] Weiming Liu . “Efficient synthesis of l-tert-leucine through reductive amination using leucine dehydrogenase and formate dehydrogenase coexpressed in recombinant E. coli.” Biochemical Engineering Journal 91 (2014): Pages 204-209.
[2] Wei Luo. “Cloning and Expression of a Novel Leucine Dehydrogenase: Characterization and L-tert-Leucine Production.” Frontiers in Bioengineering and Biotechnology (2020): 186.
[3] Longxing Wang. “Biosynthetic L-tert-leucine using Escherichia coli co-expressing a novel NADH-dependent leucine dehydrogenase and a formate dehydrogenase.” Electronic Journal of Biotechnology 47 (2020): Pages 83-88. |
| Hazard Information | Back Directory | [Chemical Properties]
White to almost white powder | [Uses]
L-tert-Leucine is an essential amino acid and makes up one third of our muscle protein. It can be used as a food additive. It is used in the formation of sterols. It is used in the production of cobalt oxazoline palladacycles complex, which acts as a catalyst in the rearrangement of prochiral N-aryl trifluoroacetimidates to allylic amides yielded in significantly higher enantioselectivities with the (S)-(pR)-diasteroisomer. | [Synthesis Reference(s)]
Organic Syntheses, Coll. Vol. 3, p. 523, 1955
Tetrahedron Letters, 19, p. 4625, 1978 DOI: 10.1016/S0040-4039(01)85688-4 |
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