| Identification | More | [Name]
4-Bromo-2-trifluoromethoxyaniline | [CAS]
175278-09-8 | [Synonyms]
2-AMINO-5-BROMO TRIFLUOROMETHOXY BENZENE
4-BROMO-2-(TRIFLUOROMETHOXY)ANILINE
BUTTPARK 50\01-74
TIMTEC-BB SBB005835
4-bromo-2-(trifluoromrthoxy)aniline
4-Bromo-2-(trifluoromethoxy)aniline 98%
4-Bromo-2-(trifluoromethoxy)aniline98%
4-Bromo-2-trifluoromethoxy-phenylamine | [Molecular Formula]
C7H5BrF3NO | [MDL Number]
MFCD00179338 | [Molecular Weight]
256.02 | [MOL File]
175278-09-8.mol |
| Chemical Properties | Back Directory | [Appearance]
clear pale yellow to orange-yellow liquid | [Boiling point ]
98-100 °C/15 mmHg (lit.) | [density ]
1.691 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.5130(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
1.75±0.10(Predicted) | [CAS DataBase Reference]
175278-09-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
R25:Toxic if swallowed.
R43:May cause sensitization by skin contact.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
2
| [Hazard Note ]
Toxic | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
29222990 |
| Hazard Information | Back Directory | [Chemical Properties]
clear pale yellow to orange-yellow liquid | [Uses]
4-Bromo-2-(trifluoromethoxy)aniline is a versatile building block that can be used to create a range of compounds, such as methyl 4- amino-3-(trifluoromethoxy)benzoate, 1-Bromo-3-(trifluoromethoxy)benzene, etc.
To a solution of 4-bromo-2-(trifluoromethoxy)aniline (10 g, 50.21 mmol) in methanol (150 mL) in a pressure tank reactor was added TEA (11.84 g, 117.01 mmol), Pd(dppf)Ci2 CH2Q2 (2.4 g, 2.94 mmol). Then the reactor was charged with CO (g) (20 atm). The resulting reaction was stirred for 1.5 days at 100°C. Then it was diluted with water (200 mL), extracted with ethyl acetate (3 x 100 mL) and the organic layers combined and dried in an oven under reduced pressure. The resulting mixture was concentrated in a vacuo. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:50) to afford methyl 4- amino-3-(trifluoromethoxy)benzoate as yellow solid (5 g, 54 %). |
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