| Identification | More | [Name]
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid | [CAS]
17257-71-5 | [Synonyms]
(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
(-)-MOSHER'S ACID
MOSHERS ACID
(-)-MTPA
(R)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYL-ACETIC ACID
(S)-(-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(S)-(-)-2-METHOXY-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(S)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(S)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(S)-(-)-MOSHER'S ACID
(S)-(-)-MPTA
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
(-)-Moshers acid~(-)-MTPA
minus-A-methoxy-A-trifluoro-methyl*phenylacetic A
(S)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL) PH ENYLACETIC ACID, 99+% (99% EE/GLC)
MINUS-A-METHOXY-A-TRIFLUORO-METHYL*PHENY LACETIC ACI
(S)-(-)-A-METHOXY-A-(TRIFLUORO-ME-)-PH-A CETIC ACID, CHIRASELECT REAG (99+%EE)
(S)-(-)-Mosheracid
(S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylaceticacid(ee) | [EINECS(EC#)]
241-292-1 | [Molecular Formula]
C10H9F3O3 | [MDL Number]
MFCD00064200 | [Molecular Weight]
234.17 | [MOL File]
17257-71-5.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless viscous liquid | [Melting point ]
46-49 °C(lit.) | [alpha ]
D24 -71.8± 0.6° (c = 3.28 in CH3OH) | [Boiling point ]
95-97 °C0.05 mm Hg(lit.) | [density ]
1.303 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.474(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
Readily soluble in hexane, ether, THF, CH2Cl2, benzene. | [form ]
Viscous Liquid or Low Melting Solid | [pka]
1.47±0.10(Predicted) | [color ]
Clear colorless or white | [Specific Gravity]
1.303 | [optical activity]
[α]20/D 73±1°, c = 2% in methanol | [Sensitive ]
Hygroscopic | [Merck ]
14,6280 | [BRN ]
3591561 | [CAS DataBase Reference]
17257-71-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
3-10 | [Hazard Note ]
Irritant/Keep Cold | [HazardClass ]
IRRITANT, HYGROSCOPIC, KEEP COLD | [HS Code ]
29189900 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless viscous liquid | [Uses]
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy. | [General Description]
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively. | [Purification Methods]
A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.] |
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