| Identification | More | [Name]
3-Hydroxy-2-nitropyridine | [CAS]
15128-82-2 | [Synonyms]
2-NITRO-3-HYDROXYPYRIDINE
2-NITRO-3-PYRIDINOL
3-HYDROXY-2-NITROPYRIDINE
3-PYRIDINOL, 2-NITRO-
TIMTEC-BB SBB004168
2-nitro-3-pyridino
2-Nitro-pyridin-3-ol
3-Hydroxy-2-Nitro Pyridine 2-Nitro-3-Hydroxy Pyridine
3-HYDROXY-2-NITROPYRIDINE 97%
3-Hydroxy-2-Nitropyrine
2-NITRO-3-HYDROPYRIDINE
3-Pyridinol,2-nitro-(6CI,8CI,9CI)
3-HYDROXY-2-NITROPYRIDINE 98+% | [EINECS(EC#)]
239-191-2 | [Molecular Formula]
C5H4N2O3 | [MDL Number]
MFCD00006258 | [Molecular Weight]
140.1 | [MOL File]
15128-82-2.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow crystalline powder | [Melting point ]
69-71 °C (lit.) | [Boiling point ]
256.56°C (rough estimate) | [density ]
1.5657 (rough estimate) | [refractive index ]
1.4800 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Crystalline Powder | [pka]
0.31±0.22(Predicted) | [color ]
Yellow | [BRN ]
124473 | [InChIKey]
QBPDSKPWYWIHGA-UHFFFAOYSA-N | [CAS DataBase Reference]
15128-82-2(CAS DataBase Reference) | [EPA Substance Registry System]
15128-82-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
UU7715000
| [Hazard Note ]
Irritant | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow crystalline powder | [Uses]
3-Hydroxy-2-nitropyridine may be used in the synthesis of novel sulfonates that are potent inhibitors of cell proliferation and tubulin polymerization. | [Preparation]
Synthesis of 3-hydroxy-2-nitropyridine: add 10g of 3-hydroxypyridine, 80ml of ethyl acetate, 4.2g of KNO3 and 21ml of acetic anhydride into a 250mL three-necked flask, and heat at 45°C with magnetic stirring After the reaction is completed, it is cooled to room temperature, filtered with suction, washed with a small amount of ethyl acetate for 1 to 2 times, the filtrate is taken to adjust the pH to neutrality with saturated NaOH solution, and extracted with ethyl acetate for 3 to 4 times. , take the extract and add activated carbon and heat under reflux for 1 hour, cool and filter, take the filtrate, dry with anhydrous magnesium sulfate, filter, concentrate on a rotary evaporator, and dry in a drying oven. 11.9 g of 3-hydroxy-2-nitropyridine was obtained with a yield of 81%. |
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