| Identification | More | [Name]
Methyl 3-aminocrotonate | [CAS]
14205-39-1 | [Synonyms]
3-AMINO-2-BUTENOIC ACID METHYL ESTER
3-AMINOCROTONATE METHYL ESTER
3-AMINOCROTONIC ACID METHYL ESTER
AMINOCROTONIC ACID METHYL ESTER
METHYL 3-AMINO-2-BUTENOATE
METHYL 3-AMINOCROTONATE
METHYL 4-AMINOCROTONATE
METHYL-BETA-AMINOCROTONATE
3-amino-2-butenoicacimethylester
3-amino-crotonicacimethylester
beta-aminocrotonicacidmethylester
methyl3-aminocrotonoate
methyl 3-amino-trans-but-2-enoate
2-Butenoic acid, 3-amino-, methyl ester
Methyl β-aminobutenate
beta-Iminomethylbutyrate
Methyl 3-iminobutyrate
Crotonic acid, 3-amino-, methyl ester
(1-Aminoethylidene)acetic acid methyl
3-Amino-2-butenoic acid methyl | [EINECS(EC#)]
238-056-5 | [Molecular Formula]
C5H9NO2 | [MDL Number]
MFCD06659463 | [Molecular Weight]
115.13 | [MOL File]
14205-39-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystals, yellowish-white | [Melting point ]
81-83 °C(lit.)
| [Boiling point ]
112°C 42mm | [density ]
1.1808 (rough estimate) | [vapor pressure ]
2.79-2.853hPa at 25℃ | [refractive index ]
1.4538 (estimate) | [Fp ]
91 °C
| [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
18g/l | [form ]
Crystalline Powder | [pka]
5.27±0.70(Predicted) | [color ]
White to slightly yellow | [PH]
8-9 (18g/l, H2O, 20℃) | [Water Solubility ]
insoluble | [Sensitive ]
Hygroscopic | [Usage]
Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet | [BRN ]
956592 | [InChIKey]
XKORCTIIRYKLLG-ONEGZZNKSA-N | [LogP]
-0.27 at 25℃ | [CAS DataBase Reference]
14205-39-1(CAS DataBase Reference) | [EPA Substance Registry System]
14205-39-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
EM9092500
| [TSCA ]
Yes | [HS Code ]
29224995 |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
Manidipine-->Amlodipine-->Nitrendipine-->Felodipine-->Benidipine-->Isradipine-->Nisoldipine-->Cilnidipine-->Phthaloyl amlodipine-->Lercanidipine hydrochloride-->2(1H)-PYRIDINONE, 4-HYDROXY-3,6-DIMETHYL--->Methyl 6-chloro-2-Methylnicotinate-->4-(2,3-Dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylic acid-->Felodipine 3,5-DiMethyl Ester-->3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide |
| Hazard Information | Back Directory | [Chemical Properties]
Crystals, yellowish-white | [Uses]
Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet | [Uses]
Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified. | [Preparation]
3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists. | [General Description]
Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin. | [Flammability and Explosibility]
Notclassified |
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