| Identification | More | [Name]
2-Cyanopyrimidine | [CAS]
14080-23-0 | [Synonyms]
2CPM
2-CPY
2-CYANOPYRIMIDINE
2-PYRIMIDINECARBONITRILE
PYRIMIDINE-2-CARBONITRILE
2-Cynopyrimidine
2-cyanpyrimidine
2-Pyrimidinecarbonitrile (6CI,7CI,8CI,9CI)
Pyrimidine-2-carbonitrile 98%
2-CYANOPYRIMIDINE, 98+%
PYRIMIDINE-2-CARBONITRILE (2-CYANOPYRIMIDINE) | [EINECS(EC#)]
604-202-5 | [Molecular Formula]
C5H3N3 | [MDL Number]
MFCD00160513 | [Molecular Weight]
105.1 | [MOL File]
14080-23-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
40-44 °C (lit.) | [Boiling point ]
250.7±23.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
Crystalline Powder | [pka]
-3.27±0.13(Predicted) | [color ]
White to yellow | [InChIKey]
IIHQNAXFIODVDU-UHFFFAOYSA-N | [CAS DataBase Reference]
14080-23-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,C,F | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R43:May cause sensitization by skin contact.
R34:Causes burns.
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
3276 | [WGK Germany ]
3
| [Hazard Note ]
Harmful | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
29335900 |
| Hazard Information | Back Directory | [Chemical Properties]
White to yellow to brown solid | [Biological Activity]
2-cyano-pyrimidine is a cathepsin k inhibitor.cathepsin k is a protease defined by its high specificity for kinins, which is involved in bone resorption. cathepsin k's ability to catabolize collagen, elastin, and gelatin allow it to break down bone and cartilage. such catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. therefore, inhibitors of cathepsin k are showing great potential in the treatment of osteoporosis. | [in vitro]
2-cyano-pyrimidine was identified as a cathepsin k inhibitor whose basic structure and derivatives have been evaluated for the treatment of osteoporosis. enzymatic study showed that 2-cyano-pyrimidine had an ic50 value of 170 nm for inhibition of cathepsin k, elevated activity of which has been linked to the formation of osteoporosis and arthritis. moreover, cathepsin k was found to be a lysosomal cysteine protease found in osteoclasts. [1,2]. | [IC 50]
170 nm | [storage]
Store at -20°C | [References]
[1] altmann, e. ,aichholz, r.,betschart, c., et al. 2-cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin k. journal of medicinal chemistry 50(4), 591-594 (2007).
[2] rankovic z et al. design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin k inhibitors. bioorg med chem lett. 2010 mar 1;20(5):1524-7. |
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