| Identification | Back Directory | [Name]
AG 18 | [CAS]
118409-57-7 | [Synonyms]
AG 18
TX 825
RG 50858
RG-50810
AG18, >=98%
TYRPHOSTIN 23
TYRPHOSTIN A23
Tyrphostin AG 1
AG-18(RG-50810)
TYRPHOSTIN AG 18
RARECHEM AL BX 0069
TYRPHOSTIN RG 50858
TYRPHOSTIN A23 99+%
AG 18 (Tyrphostin 23)
AG 18 (Tyrphostin A23)
AG 18 (pharmaceutical)
α-Cyano-(3,4-dihydroxy)cinnamonitrile
4,5-Dihydroxybenzylidenemalononitrile
[3,4-DIHYDROXYBENZYLIDENE]MALONONITRILE
ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMONITRILE
2-(3,4-Dihydroxybenzylidene)malononitrile
α-Cyano-(3,4-dihydroxy)cinnamonitrile
(3,4-Dihydroxyphenyl)methylene propanedinitrile
2-(3,4-Dihydroxyphenyl)ethene-1,1-dicarbonitrile
[(3,4-DIHYDROXYPHENYL)METHYLENE]-PROPENEDINITRILE
(3,4-Dihydroxybenzylidene)-malononitrile, RG-50810
Propanedinitrile, ((3,4-dihydroxyphenyl)methylene)-
Propanedinitrile, 2-[(3,4-dihydroxyphenyl)methylene]-
AG 18 (3,4-Dihydroxybenzylidene)malononitrile 2-(3,4-Dihydroxybenzylidene)malononitrile | [Molecular Formula]
C10H6N2O2 | [MDL Number]
MFCD00133899 | [MOL File]
118409-57-7.mol | [Molecular Weight]
186.17 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Powder | [Melting point ]
225°C | [Boiling point ]
421.1±45.0 °C(Predicted) | [density ]
1.428±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in DMSO, ethanol, or DMF | [form ]
Yellow solid | [pka]
7.26±0.18(Predicted) | [color ]
Yellow | [biological source]
synthetic (organic) | [λmax]
464nm(DMSO)(lit.) | [Stability:]
Store in refrigerator |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Powder | [Uses]
A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM) | [Uses]
AG 18 inhibits EGFR with IC50 of 35 μM. | [Biological Activity]
Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling. | [Definition]
ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols. | [Biochem/physiol Actions]
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,. | [storage]
Store at -20°C |
|
|