| Identification | More | [Name]
Cyclopentadecanolide | [CAS]
106-02-5 | [Synonyms]
15-HYDROXYPENTADECANOIC ACID LACTONE
15-PENTADECANOLACTONE
15-PENTADECANOLIDE
1-OXA-2-CYCLOHEXADECANONE
CYCLOPENTADECANOLIDE
FEMA 2840
OMEGA-PENTADECALACTONE
O-PENTADECALACTONE
OXACYCLOHEXADECAN-2-ONE
PENTADECANOLIDE
PENTALIDE
W-PENTADECALACTONE
1,15-Pentadecanolide
15-hydroxy-pentadecanoicacixi-lactone
2-Pentadecalone
Cyclopentadecanolactone
Exaltolide
Muskalactone
Muskolactone
Pentadecalactone | [EINECS(EC#)]
203-354-6 | [Molecular Formula]
C16H28O2 | [MDL Number]
MFCD00039667 | [Molecular Weight]
252.39 | [MOL File]
106-02-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline low melting solid | [Melting point ]
34-38 °C(lit.)
| [Boiling point ]
137 °C2 mm Hg(lit.)
| [density ]
0.918 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.085Pa at 25℃ | [FEMA ]
2840 | [refractive index ]
1.4700 | [Fp ]
>230 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Ethyl Acetate, Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Odor]
at 10.00 % in dipropylene glycol. musk animal powdery natural fruity | [Odor Type]
musk | [Water Solubility ]
Soluble in alcohol, dipropylene glycol. Insoluble in water. | [JECFA Number]
239 | [Merck ]
14,3910 | [BRN ]
143710 | [LogP]
5.79 at 25℃ | [CAS DataBase Reference]
106-02-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Oxacyclohexadecan-2-one(106-02-5) | [EPA Substance Registry System]
106-02-5(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
1
| [RTECS ]
RN9775000
| [TSCA ]
Yes | [HS Code ]
29322090 | [Toxicity]
Both the acute oral LD50 value in rats and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Levenstein, 1974). |
| Hazard Information | Back Directory | [Chemical Properties]
Cyclopentadecanolide occurs in small quantities in,
for example, angelica root oil. It forms colorless crystals (mp 37–38°C) with a
delicate, musk-like odor. | [Chemical Properties]
white crystalline low melting solid | [Chemical Properties]
ω-Pentadecalactone has an extraordinarily persistent, musk-like odor. | [Occurrence]
Originally reported found in the essential oil from angelica roots. | [Uses]
As a fixative in perfumery. | [Definition]
ChEBI: Cyclopentadecanolide is a macrolide. | [Preparation]
The main industrial syntheses start from compounds produced
from cyclododecatriene: either by ring expansion of cyclododecanone or
by depolymerization of polyesters of 15-hydroxypentadecanoic acid (from
1,12-dodecanediol). | [Aroma threshold values]
Detection: 1 to 4 ppb | [Taste threshold values]
Taste characteristics at 75 ppm: vanilla bean, powdery helioropine, creamy and licorice. | [Synthesis Reference(s)]
Tetrahedron Letters, 34, p. 6107, 1993 DOI: 10.1016/S0040-4039(00)61741-0
The Journal of Organic Chemistry, 50, p. 2394, 1985 DOI: 10.1021/jo00213a044 | [General Description]
Pentadecanolide is one of the major components, isolated from the root of Angelica archangelica L., species. It is a synthetic musk, which exists as a widespread contaminant in the environment. | [Flammability and Explosibility]
Nonflammable | [Trade name]
Macrolide® (Symrise), Exaltolide®, Exaltolide®Total (Firmenich),
Pentalide (Soda Aromatic). | [Purification Methods]
It has been recrystallised from MeOH (4 parts) at -15o. [Hundieck |
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