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ChemicalBook CAS DataBase List Valdecoxib IMpurity B
1373038-60-8

Valdecoxib IMpurity B synthesis

5synthesis methods
37928-17-9 Synthesis
5-Methyl-3,4-diphenylisoxazole

37928-17-9
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Valdecoxib IMpurity B

1373038-60-8
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: chlorosulfonic acid / dichloromethane / 0 °C / Reflux
1.2: 1 h / 25 - 35 °C
2.1: pyridine / 9 h / 110 - 115 °C

References:

Reddy, Anumula Raghupathi;Goverdhan, Gilla;Sampath, Aalla;Mukkanti, Khagga;Reddy, Padi Pratap;Bandichhor, Rakeshwar [Synthetic Communications,2012,vol. 42,# 5,p. 639 - 649]

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