4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole synthesis
1synthesis methods
- Product Name:4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole
- CAS Number:1448355-87-0
- Molecular formula:C16H12ClNO
- Molecular Weight:269.73
Yield:1448355-87-0 73%
Reaction Conditions:
with palladium(II) acetylacetonate;N,N,N,N,-tetramethylethylenediamine;copper(I) bromide in 1-methyl-pyrrolidin-2-one at 170; for 3 h;Inert atmosphere;chemoselective reaction;
References:
Cahiez, Gerard;Moyeux, Alban;Gager, Olivier;Poizat, Mael [Advanced Synthesis and Catalysis,2013,vol. 355,# 4,p. 790 - 796] Location in patent:supporting information