TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL synthesis
- Product Name:TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL
- CAS Number:433-27-2
- Molecular formula:C4H7F3O2
- Molecular Weight:144.09
Yield:-
Reaction Conditions:
with C28H29ClNOP2Ru;potassium ethoxide;hydrogen in ethanol at 38; under 6000.6 Torr;Autoclave;
Steps:
4
A pressure-proof reaction vessel of stainless steel (SUS) was charged with 14 g (100 mmol, 1 eq) of α-fluoroesterof the following formula, 6.4 mg (purity: 94.2%; 10 mmol, 0.0001 eq) of ruthenium complex of the following formula, 840mg (10.0 mmol, 0.1 eq) of potassium ethoxide and 44 mL (0.4 L/mol) of ethanol. The inside of the reaction vessel was replaced five times with hydrogen gas. The hydrogen pressure inside the reactionvessel was then set to 0.8 MPa. The resulting solution inside the reaction vessel was stirred all night at 38°C. It wasconfirmed by 19F-NMR analysis of the reaction completed solution that the conversion rate of the reaction and theselectivity of α-fluoroaldehyde equivalent of the following formula were 91% and 83.0%, respectively. It was also confirmed that the selectivity of β-fluoroalcohol of the following formula as an excessive reduction productwas 17.0%.
References:
Central Glass Company, Limited;ISHII, Akihiro;OOTSUKA, Takashi;IMAMURA, Mari;NISHIMIYA, Takayuki;KIMURA, Kazuto EP2740719, 2014, A1 Location in patent:Paragraph 0057
383-63-1
482 suppliers
$10.00/25 g
433-27-2
140 suppliers
$12.00/1g
64-17-5
717 suppliers
$10.00/50g
431-47-0
283 suppliers
$10.00/5g
75-89-8
472 suppliers
$9.00/1g
431-46-9
72 suppliers
$9.00/1g
433-27-2
140 suppliers
$12.00/1g
1254592-76-1
3 suppliers
inquiry
433-27-2
140 suppliers
$12.00/1g
