ChemicalBook CAS DataBase List Topiramate

Topiramate synthesis

8synthesis methods

Product Name:Topiramate
CAS Number:97240-79-4
Molecular formula:C12H21NO8S
Molecular Weight:339.36

Ziconitide is the synthetic form of the conotoxin ω-conopeptide MVIIA .

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Yield:97240-79-4 96.7%

Reaction Conditions:

with ammonia in tetrahydrofuran;hexane at 20; for 3 h;Solvent;Temperature;

Steps:

4-6; 7.2; 8.2; 1.3; 2.2; 3.2; 4.2; 5 Embodiment 4TopiramatePreparation

Weigh 17.3 g of 2,3: 4,5-bis-O- (1-methylethylene) -β-D-fructopyranosyl chlorosulfonate Form A prepared in Example 1 in 300 mL of mixed solvent (Tetrahydrofuran: n-hexane = 20: 80), pass in ammonia gas, react at room temperature for 3h, filter, and concentrate under reduced pressure to about 40mL of the remaining filtrate.Cool to -5 0 to crystallize, filter and dry to obtain 15.8g of white solid (ie: topiramate),Yield: 96.7%, HPLC purity: 99.93%;2,3: 4,5-bis-O- (1-methylethylene) -β-D-fructofuranose: 0.02%; condensate: 0.03%.

References:

CN110655542,2020,A Location in patent:Paragraph 0057-0062; 0063; 0066-0068; 0071; 0072; 0078; 0079

20880-92-6 Synthesis