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ChemicalBook >> CAS DataBase List >> Topiramate

Topiramate

Topiramate price.
  • $5 - $849
  • Product name: Topiramate
  • CAS: 97240-79-4
  • MF: C12H21NO8S
  • MW: 339.36
  • EINECS:619-263-3
  • MDL Number:MFCD00865320
  • Synonyms:2,3:4,5-Bis-O-(1-methylethylidene)--D-fuctopyranose Sulfamate, McN-4853, RWJ-17021-000, Topamax;McN 4853, RWJ 17021, Topamax, 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-36-D-FRUCTO-PYRANOSE SULFAMATE;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-B-D-FUCTO-PYRANOSE SULFAMATE;2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranose sulfamate;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-BETA-D-FUCTOPYRANOSE SULFAMATE;RWJ 17021;RWJ-17021-000
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
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  • DC Chemicals
  • Medical Isotopes, Inc.
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  • Usbiological
Package
  • Y0002134
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  • 1mL
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  • 25g
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  • 10mM(in 1mL DMSO)
  • 100g
  • 500g
  • 1ml of 1mg
  • 250g
  • 1KG
  • ManufacturerAK Scientific
  • Product numberJ95743
  • Product descriptionTopiramate
  • Packaging1g
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA206081
  • Product descriptionTopiramate 98%
  • Packaging500g
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA206081
  • Product descriptionTopiramate 98%
  • Packaging100g
  • Price$73
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA206081
  • Product descriptionTopiramate 98%
  • Packaging25g
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA206081
  • Product descriptionTopiramate 98%
  • Packaging10g
  • Price$17
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA206081
  • Product descriptionTopiramate 98%
  • Packaging5g
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA206081
  • Product descriptionTopiramate 98%
  • Packaging1g
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA206081
  • Product descriptionTopiramate 98%
  • Packaging100mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004451
  • Product descriptionTOPIRAMATE 95.00%
  • Packaging1G
  • Price$825
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004451
  • Product descriptionTOPIRAMATE 95.00%
  • Packaging5MG
  • Price$508
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4360
  • Product descriptionTopiramate
  • Packaging100mg
  • Price$62
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4360
  • Product descriptionTopiramate
  • Packaging10mM(in 1mL DMSO)
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS476763
  • Product descriptionTopiramate 98%
  • Packaging1g
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS476763
  • Product descriptionTopiramate 98%
  • Packaging5g
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS476763
  • Product descriptionTopiramate 98%
  • Packaging10g
  • Price$17
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS476763
  • Product descriptionTopiramate 98%
  • Packaging25g
  • Price$27
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J95743 Topiramate 1g $68 2021-12-16 Buy
Ambeed A206081 Topiramate 98% 500g $260 2021-12-16 Buy
Ambeed A206081 Topiramate 98% 100g $73 2021-12-16 Buy
Ambeed A206081 Topiramate 98% 25g $27 2021-12-16 Buy
Ambeed A206081 Topiramate 98% 10g $17 2021-12-16 Buy
Ambeed A206081 Topiramate 98% 5g $9 2021-12-16 Buy
Ambeed A206081 Topiramate 98% 1g $6 2021-12-16 Buy
Ambeed A206081 Topiramate 98% 100mg $5 2021-12-16 Buy
American Custom Chemicals Corporation API0004451 TOPIRAMATE 95.00% 1G $825 2021-12-16 Buy
American Custom Chemicals Corporation API0004451 TOPIRAMATE 95.00% 5MG $508 2021-12-16 Buy
ApexBio Technology A4360 Topiramate 100mg $62 2021-12-16 Buy
ApexBio Technology A4360 Topiramate 10mM(in 1mL DMSO) $67 2021-12-16 Buy
Arctom AS476763 Topiramate 98% 1g $6 2021-12-16 Buy
Arctom AS476763 Topiramate 98% 5g $9 2021-12-16 Buy
Arctom AS476763 Topiramate 98% 10g $17 2021-12-16 Buy
Arctom AS476763 Topiramate 98% 25g $27 2021-12-16 Buy

Properties

Melting point :125°C
alpha :D23 -34.0° (c = 0.4 in methanol)
Boiling point :438.7±55.0 °C(Predicted)
Density :1.336±0.06 g/cm3(Predicted)
Flash point :9℃
storage temp. :2-8°C
solubility :DMSO: ~44 mg/mL
form :solid
pka :9.22±0.70(Predicted)
color :white
Water Solubility :9.705g/L(temperature not stated)
Merck :14,9547
BCS Class :3
LogP :2.970 (est)
EPA Substance Registry System :.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate (97240-79-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Topiramate is a sugar sulfamate that exhibits potent anticonvulsant activity. It completely blocks seizures (ED50 = 39 mg/kg when given orally) in mice in the maximal electroshock seizure test. This effect is sustained for over eight hours. In the rotoreel test of neurotoxicity, topiramate has a peak neurotoxic dose ED50 value of 407 mg/kg in mice at one hour. It is virtually inactive against seizures caused by pentylenetetrazol, bicuculline, picrotoxin, and strychnine. It does not bind to norepinephrine, serotonin, γ-amino butyric acid, muscarinic, or dopamine receptors. The drug form of Topiramate, Topamax?, is used alone or with other medications to treat seizures associated with epilepsy and to prevent migraine headaches.

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