Thymine synthesis

9synthesis methods

Product Name:Thymine
CAS Number:65-71-4
Molecular formula:C5H6N2O2
Molecular Weight:126.11

5-Methylpyrimidine is an important part of genetic material, a key intermediate in the synthesis of anti-AIDS drugs AZT, DDT and related drugs, and a raw material for the synthesis of anti-tumor and antiviral drugs β-thymidine. The synthesis method of thymine is that ethyl formate and ethyl propionate as raw materials, condensed with urea under acid catalysis, and cyclized under the action of sodium methoxide to obtain 5-Methylpyrimidine, yield 47%.

80-43-3
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66-22-8 Synthesis

66-22-8
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65-71-4
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Yield:65-71-4 87%

Reaction Conditions:

with acetic acid at 120;

Steps:

20.1 (1) Synthesis of compound 20-2:

To the reactor was added pyrimidine-2,4-dione 20-1 (0.112 g, 1 mmol)Dicumyl peroxide (0.81 g, 3 mmol) and 2 ml of acetic acid,Reaction at 120 ° C, TLC followed the reaction.The crude product obtained after concentration was purified by column chromatography (petroleum ether: ethyl acetate = 1: 1)And purified to give the title product 20-2 (yield 87%)

References:

CN106496130,2017,A Location in patent:Paragraph 0039

22423-26-3 Synthesis