TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE synthesis

11synthesis methods

Product Name:TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE
CAS Number:77278-63-8
Molecular formula:C15H22N2O2
Molecular Weight:262.35

92-54-6 Synthesis

92-54-6
410 suppliers
$13.00/5g

24424-99-5 Synthesis

24424-99-5
832 suppliers
$13.50/25G

TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE

77278-63-8
53 suppliers
$60.00/100mg

Yield:77278-63-8 99%

Reaction Conditions:

with 3a,6a-diphenylglycoluril in ethanol at 25 - 30; for 0.5 h;Reagent/catalyst;

Steps:

6. General procedure of diphenylglycoluril catalyzed N-tertbutoxycarbonylationof amines 3a-y

General procedure: In a 25 mL of round bottom flask, a solution of di-tert-butyldicarbonate (1 mmol) and Diphenyglycouril (10 mol %) were addedin 10 mL of ethanol. A turbid solutionwas obtained. In that solution1 mmol of Amine (1a-y) was added. Reaction mixture was stirredfor 30 min at room temperature. After total consumption of thestarting material (determination by TLC), the solvent was removedin vacuo, and the residue was isolated by column chromatographyon silica gel to get the pure product 3a-y as solid or oil.

References:

Awasthi, Amardeep;Mukherjee, Anagh;Singh, Mandeep;Rathee, Garima;Vanka, Kumar;Chandra, Ramesh [Tetrahedron,2020,vol. 76,# 23,art. no. 131223] Location in patent:supporting information

108-86-1 Synthesis