ChemicalBook CAS DataBase List PIVALAMIDE

PIVALAMIDE synthesis

9synthesis methods

Product Name:PIVALAMIDE
CAS Number:754-10-9
Molecular formula:C5H11NO
Molecular Weight:101.15

3282-30-2
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$18.00/100ml

3863-11-4 Synthesis

3863-11-4
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$10.00/25 g

754-10-9
172 suppliers
$7.00/5g

Yield:-

Reaction Conditions:

with triethylamine in dichloromethane

Steps:

13.A Part A:
Part A: Preparation of N-trimethylacetyl-3,4-difluoroandlide. To a solution of 3,4-difluoroaniline (19 mL, 191 mmol) in methylene chloride (500 mL) at 0° was added triethylamine (32 mL, 230 mmol) followed dropwise with trimethylacetyl chloride (24 mL, 191 mmol) and the resulting reaction mixture was allowed to stir at room temperature for 3 h. The reaction mixture was poured onto 3N HCl ard extracted with methylene chloride (3*100 mL) and the combined organic extracts were dried over anhydrous NaSO₄ and concentrated in vacuo. The residue was taken up in hexanes (300 mL) and filtered through a sintered glass funnel. The solids are washed thoroughly with hexanes (500 mL) and dried under vacuum to give 37.36 g of the pivaloyl amide as a solic (40.68 g theoretical, 92% yield).

References:

Dupont Pharmaceuticals Company US6140320, 2000, A