(+)-Pilocarpine hydrochloride synthesis
- Product Name:(+)-Pilocarpine hydrochloride
- CAS Number:54-71-7
- Molecular formula:C11H17ClN2O2
- Molecular Weight:244.72
![2(3H)-Furanone, 3-ethylidenedihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (4R)-](/CAS/20210111/GIF/1192231-13-2.gif)
1192231-13-2
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Yield:-
Reaction Conditions:
Stage #1:(R)-3-ethylidene-4-[(1-methylimidazol-5-yl)methyl]tetrahydrofuran-2-one with platinum(IV) oxide;hydrogen in methanol at 20; for 24 h;
Stage #2: with hydrogenchloride in ethanol;water at 0;Cooling;
References:
Davies, Stephen G.;Roberts, Paul M.;Stephenson, Peter T.;Storr, Helen R.;Thomson, James E. [Tetrahedron,2009,vol. 65,# 39,p. 8283 - 8296] Location in patent:experimental part