PENTAFLUOROPHENYL TRIFLUOROMETHANESULFONATE synthesis
- Product Name:PENTAFLUOROPHENYL TRIFLUOROMETHANESULFONATE
- CAS Number:60129-85-3
- Molecular formula:C7F8O3S
- Molecular Weight:316.13
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Yield:-
Reaction Conditions:
with pyridine in dichloromethane at 0 - 20; for 5 h;
Steps:
2. Preparation of Aryl Triflates
General procedure: To a solution of phenol (1.0 equiv) and pyridine (2.0 equiv) in DCM was added dropwise trifluoromethanesulfonic anhydride (1.2 equiv) at 0 °C. Then the mixture was warmed to room temperature and stirred for 5 hours. The reaction was quenched with HCl (1M). The mixture was diluted with ethyl acetate. The organic layer was washed with sat. NaHCO3, water, brine successively and concentrated under reduced pressure. The crude residue was purified with a flash column chromatography.
References:
Chen, Hui;Liao, Xuebin [Tetrahedron,2019,vol. 75,# 31,p. 4186 - 4191] Location in patent:supporting information