ChemicalBook CAS DataBase List Nicotinamide riboside

Nicotinamide riboside synthesis

6synthesis methods

Product Name:Nicotinamide riboside
CAS Number:1341-23-7
Molecular formula:C11H15N2O5+
Molecular Weight:255.25

Pyridinium, 3-(aminocarbonyl)-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-

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Yield:1341-23-7 95.6%

Reaction Conditions:

with triethylamine in ethanol at -5 - 35; for 4.5 h;Reagent/catalyst;

Steps:

1.2 (2) Debenzoyl protection group

The nicotinamide tribenzoyl nucleoside obtained by the above reaction was dissolved in 300ml of absolute ethanol, the temperature was lowered to -5°C, 40ml of triethylamine was added dropwise under stirring, and the rate of dropping was controlled. Because the temperature of the reaction would rise during the reaction, control The temperature cannot exceed -5°C, the addition is completed in about 1.5 hours, stirred for 30 minutes, heated to 35°C, and reacted for 2.5 hours; after the reaction is detected by HPLC, a certain amount of dilute hydrochloric acid is added dropwise until the reaction system is neutral. Add 200 ml of methyl tertiary ether and obtain an organic phase under stirring. When the temperature was lowered to 0°C, a product was precipitated, and the nicotinamide riboside salt was obtained by separating and drying under reduced pressure with a yield of 95.6% and a quantitative purity of 93.8% by HPLC.

References:

CN113621009,2021,A Location in patent:Paragraph 0040; 0044-0045

98-92-0 Synthesis