N-Isopropylacrylamide synthesis

8synthesis methods

Product Name:N-Isopropylacrylamide
CAS Number:2210-25-5
Molecular formula:C6H11NO
Molecular Weight:113.16

107-13-1 Synthesis

107-13-1
410 suppliers
$16.00/25ML

67-63-0 Synthesis

67-63-0
1581 suppliers
$16.00/25ML

2210-25-5
330 suppliers
$9.00/5g

Yield:2210-25-5 82.3%

Reaction Conditions:

with sulfuric acid;tetrabutyl-ammonium chloride;hydroquinone in water at 20 - 50; for 1 h;Large scale;Green chemistry;

Steps:

2 Example 2
To a 200-liter stainless steel tank was added 10.6 kg of acrylonitrile, 12.6 kg of isopropanol, and 0.1 kg of 1,4-benzenediol. 0.15 kg of tetra-n-butylammonium chloride, 51.5 kg of 45% sulfuric acid was added dropwise between 20-40° C., and the reaction was completed at 40-50° C. for 1 hour after the dropwise addition. 25% aqueous ammonia was added dropwise to the reaction kettle to adjust the pH to about 8. The mixture was allowed to stand and was separated. The aqueous phase was discarded, and 130 kg of water was added to the reaction vessel. The mixture was stirred and extracted at 85° C. for 15 minutes. The mixture was allowed to stand for liquid separation. The aqueous phase was transferred to another 200 litre stainless steel kettle and the temperature was lowered to 5°C and stirred for 2 hours. After centrifugation, the solids were collected, transferred to a vacuum drying oven, and dried at 40-50° C. under a vacuum of -0.08 MPa for 4 hours to obtain 18.6 kg of N-isopropylacrylamide with a yield of 82.3% and a liquid phase purity of 98.1%.

References:

Liaoning San Yang New Materials Technology Co., Ltd.;Yu Tao;Zhang Zequn CN107445856, 2017, A Location in patent:Paragraph 0023

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75-31-0 Synthesis