ChemicalBook CAS DataBase List N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone

N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone synthesis

6synthesis methods

Product Name:N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone
CAS Number:39108-47-9
Molecular formula:C11H14N2O2
Molecular Weight:206.24

105-45-3
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109-73-9 Synthesis

109-73-9
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N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone

39108-47-9
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Yield: 237 g

Reaction Conditions:

Stage #1:N-butylamine;methyl 2-cyanoacetate at 100; for 5 h;
Stage #2:acetoacetic acid methyl ester with piperidine at 100; for 5 h;

Steps:

1
200 g of methyl cyanoacetate and 136 g of butylamine were mixed,After stirring at 100 ° C. for 5 hours, 226 g of methyl acetoacetate,Subsequently, 181 g of piperidine was added dropwise and the mixture was stirred at 100 ° C. for 5 hours.After cooling the reaction solution to room temperature, the reaction solution was added dropwise to 2000 g of 7.2 wt% hydrochloric acid vigorously stirred.The precipitate obtained by filtration was stirred and washed with 400 g of acetone / 600 g of water,After filtration, it was dried by heating under vacuum to obtain 237 g of compound (a).

References:

NIPPON SHOKUBAI COMPANY LIMITED;SHINGUBARA, KOJI;TATSUMI, HIRONORI;KITAMURA, MORIHIRO;MASUDA, KIYOSHI JP5727321, 2015, B2 Location in patent:Paragraph 0128; 0130; 0131

141-97-9 Synthesis