ChemicalBook CAS DataBase List N-Boc-Piperidine-4-carboxylic acid methyl ester

N-Boc-Piperidine-4-carboxylic acid methyl ester synthesis

12synthesis methods

Product Name:N-Boc-Piperidine-4-carboxylic acid methyl ester
CAS Number:124443-68-1
Molecular formula:C12H21NO4
Molecular Weight:243.3

2971-79-1 Synthesis

2971-79-1
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$10.00/10g

24424-99-5 Synthesis

24424-99-5
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$13.50/25G

N-Boc-Piperidine-4-carboxylic acid methyl ester

124443-68-1
264 suppliers
$6.00/5g

Yield:124443-68-1 98%

Reaction Conditions:

with triethylamine in dichloromethane at 25; for 12 h;Product distribution / selectivity;

Steps:

A.2.1

Synthesis of 9-(Azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane Trifluoroacetate (A4); Step-1: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; To a stirred solution of methyl isonipecotate (127.2 mmol, 1 eq) in dichloromethane (200 ml) were added di-tert-butyldicarbonate (190.8 mmol, 1.5 eq) and triethylamine (254.4 mmol, 2.0 eq). The reaction mixture was stirred for 12 h at 25° C. It was then diluted with dichloromethane (100 ml) and washed with water (50 ml) and brine (50 ml). The organic layer was separated, dried over Na₂SO₄, concentrated and employed in the next step without further purification. Yield: 98%

References:

US2010/113417,2010,A1 Location in patent:Page/Page column 36

67-56-1 Synthesis