ChemicalBook CAS DataBase List N-Boc-piperidine-2-methanol

N-Boc-piperidine-2-methanol synthesis

7synthesis methods

Product Name:N-Boc-piperidine-2-methanol
CAS Number:157634-00-9
Molecular formula:C11H21NO3
Molecular Weight:215.29

24424-99-5 Synthesis

24424-99-5
832 suppliers
$13.50/25G

3433-37-2 Synthesis

3433-37-2
257 suppliers
$7.00/5g

157634-00-9
210 suppliers
$5.00/1g

Yield:157634-00-9 100%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 16 h;

Steps:

INTERMEDIATE 28 (METHOD Z); ferf-Butyl 2-(hydroxymethyl^*)piperidine- 1 -carboxylate; To a stirred solution of 2-piperidinemethanol (3.0 g, 25.60 mmol) in DCM (100 mL) was added triethylamine (14.5 mL, 91.08 mmol) and then di-tert-butyl dicarbonate (7.2 g, 31.0 mmol) portionwise. The reaction mixture was stirred at r.t. for 16 h. Water (70 mL) was added and the layers were separated. The organic layer was washed with water (2 x 50 mL), dried (Na₂SO₄), filtered and concentrated in vacuo to give the title compound (6.0 g, quantitative) as a pale brown oil that was used without further purification. δ_H (CDCl₃) 4.42-4.22 (IH, m), 4.05-3.91 (IH, m), 3.89-3.77 (IH, m), 3.71- 3.53 (IH, m), 2.97-2.81 (IH, m), 2.32-2.08 (IH, m), 1.90 (IH, s), 1.77-1.57 (3H, m), 1.54 (IH, s), 1.52-1.38 (1OH, m).

References:

WO2007/141504,2007,A1 Location in patent:Page/Page column 57

98303-20-9 Synthesis