METHYL 3-AMINOBENZOATE synthesis
- Product Name:METHYL 3-AMINOBENZOATE
- CAS Number:4518-10-9
- Molecular formula:C8H9NO2
- Molecular Weight:151.16
Yield:4518-10-9 100%
Reaction Conditions:
with thionyl chloride at 0; for 24 h;Reflux;
Steps:
1 6.2.1 General procedure for the synthesis of methyl aminobenzoates 39b-42b
General procedure: A solution of the appropriate 2-aminobenzoic acid (1equiv) in MeOH was cooled to 0°C followed by a dropwise addition of thionyl chloride (2.5equiv). The mixture was refluxed for 24h. After evaporation of the solvent and neutralization by addition of a saturated aqueous NaHCO3 solution, the mixture was extracted with EtOAc and the combined organic layers were dried over MgSO4. Purification by CC (n-hexane/EtOAc) provided the title compounds.
References:
Hinsberger, Stefan;De Jong, Johannes C.;Groh, Matthias;Haupenthal, J?rg;Hartmann, Rolf W. [European Journal of Medicinal Chemistry,2014,vol. 76,p. 343 - 351]
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