ChemicalBook CAS DataBase List L-Glutamine

L-Glutamine synthesis

5synthesis methods

Product Name:L-Glutamine
CAS Number:56-85-9
Molecular formula:C5H10N2O3
Molecular Weight:146.14

By isolation from sugar beet juice.

13726-85-7
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$10.00/5g

56-85-9
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$5.00/5g

Yield:56-85-9 40%

Reaction Conditions:

with trifluoroacetic acid at 0 - 35;Reagent/catalyst;Temperature;

Steps:

1; 3.II.C L-Glutamine preparation:

Trifluoroacetic acid (4 vol) was added to the above gummy mass (obtained from the above reaction) at 0-10°C and the reaction mass was allowed to heat at 25- 35°C and stirred for 2-3 hrs. After completion of the reaction, the excess TFA was distilled under reduced pressure and aqueous ammonia (4 vol) was added then distilled ~ 2 vol under reduced pressure at below 55°C. Methanol (6 vol) was added to the aqueous mass at 25-35°C and cooled to 0-10°C then stirred for 1 hr. The obtained white solid was filtered and washed with methanol (2 vol). The titled compound was dried under reduced pressure at 70-75°C for ~5 hrs to get the 40% of the theoretical yield.

References:

WO2022/13706,2022,A1 Location in patent:Page/Page column 13; 14; 15; 16

2490-97-3 Synthesis