ChemicalBook CAS DataBase List Isobutyrophenone

Isobutyrophenone synthesis

13synthesis methods

Product Name:Isobutyrophenone
CAS Number:611-70-1
Molecular formula:C10H12O
Molecular Weight:148.2

Isobutyrophenone synthesis: Benzene underwent a Friedel–Crafts acylation with isobutyryl chloride to synthesize isobutyrophenone. The reaction was performed using excess benzene as a replacement for a typical solvent and heat to reflux (88 °C) for a period of 3 hours. Any unreacted benzene was recovered after the reaction during the distillation process. A 66 % yield of isobutyrophenone was obtained from the solar synthesis, compared to a 44 % yield from an in-lab, electrical heating analysis.
Isobutyrophenone synthesis

79-30-1 Synthesis

79-30-1
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$10.00/10g

71-43-2
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$11.19/25ML

611-70-1
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$6.00/5g

Yield:611-70-1 95%

Reaction Conditions:

with aluminum (III) chloride at 5;

Steps:

1.a
123g of aluminum chloride (1.02 moles) were added in portions in two hours to a solution of 12Og of benzene (1.53 moles) and 108.2g of isobutyryl chloride (1.02 moles) under stirring keeping the temperature at 5⁰C. The mixture was maintained under stirring for an additional hour without cooling. The reaction was checked by TLC (Siθ2, toluene). The mixture was poured in ice under stirring. The organic layer was separated and the solvent evaporated under vacuum and the product was distilled at 163⁰C, 160mmHg obtaining 14Og of colorless oil (95% yield) that was used for the next steps

References:

LAMBERTI SPA WO2009/135895, 2009, A1 Location in patent:Page/Page column 11

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