INDOXYL ACETATE synthesis
- Product Name:INDOXYL ACETATE
- CAS Number:608-08-2
- Molecular formula:C10H9NO2
- Molecular Weight:175.18
26340-47-6
77 suppliers
$55.00/250mg
563-63-3
273 suppliers
$7.00/1g
608-08-2
218 suppliers
$36.00/1g
Yield:608-08-2 41%
Reaction Conditions:
with acetic acid at 90; for 1 h;
Steps:
2
Into a 500 mL round bottom flask was placed a solution of 3-iodo-lH-indole (23 g, 94.65 mmol) in acetic acid (300 mL). To the mixture was added CH3COOAg (31.6 g, 189.22 mmol). The resulting solution was allowed to react, with stirring, for 1 hour while the temperature was maintained at 90 °C in a bath of oil. The reaction progress was monitored by TLC (ethyl acetate/petroleum ether = 1:1). A filtration was performed. The filtrate was concentrated by evaporation under vacuum using a rotary evaporator. The resulting solution was dissolved with 100 mL of ethyl acetate. The resulting mixture was washed 2 times with 100 mL of NaCl(aq.). The final product was purified by recrystallization from MeOHTH2O in the ratio 2:3. This resulted in 8.5 g (41%) of lH-indol-3-yl acetate as a dark purple solid.
References:
MEMORY PHARMACEUTICALS CORPORATION WO2007/98418, 2007, A1 Location in patent:Page/Page column 112
480-93-3
67 suppliers
$145.00/100mg
108-24-7
5 suppliers
$14.00/250ML
608-08-2
218 suppliers
$36.00/1g
120-72-9
632 suppliers
$6.00/25g
2570-63-0
39 suppliers
$110.00/10 gm
608-08-2
218 suppliers
$36.00/1g
120-72-9
632 suppliers
$6.00/25g
608-08-2
218 suppliers
$36.00/1g