IFOSFAMIDE IMPURITY F synthesis
- Product Name:IFOSFAMIDE IMPURITY F
- CAS Number:81485-04-3
- Molecular formula:C5H11Cl2NO2P-
- Molecular Weight:219.0261
Yield:81485-04-3 68.11 %
Reaction Conditions:
with potassium carbonate in 1,4-dioxane at 90;Temperature;
Steps:
1.2-4.2
2) take 76.20g (0.77mol) of 1,2-dichloroethane and 145.12g (1.05mol) of anhydrous potassium carbonate to 700mL of dioxane, mix well, add 108.84g (0.7mol) of compound I, heat to 90 °C and stir for N-alkylation reaction for 48h, after the reaction is completed, cooling, filtration, concentration, column chromatography, and then recrystallization with ether-cyclohexane mixture with a volume ratio of 1.8:1, This yields 103.95g compound II, with a yield of 68.11%.
References:
CN115505003,2022,A Location in patent:Paragraph 0037; 0041; 0046; 0049-0050
31190-87-1
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