ChemicalBook CAS DataBase List Glycopyrrolate

Glycopyrrolate synthesis

5synthesis methods

Product Name:Glycopyrrolate
CAS Number:596-51-0
Molecular formula:C19H28BrNO3-
Molecular Weight:398.33

74-83-9
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$28.30/1ML

1-methylpyrrolidin-3-yl cyclopentylphenylglycolate

13118-11-1
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$679.13/10MG

596-51-0
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$10.00/10mg

Yield:596-51-0 144 g

Reaction Conditions:

in acetonitrile at -10 - 20; for 12 h;

Steps:

1.4; 1.5

260 g of intermediate III obtained in step 3 was dissolved by heating to 310 g of acetonitrile, cooled down to -10 DEG C, 167 g of methyl bromide was introduced, and the temperature was raised to room temperature for 12 hours.Filtration gave 311 g of crude glycopyrrolate; The crude glycopyrrolate was recrystallized from butanone to obtain 144 g of glycopyrrolate qualified product.The yield of the target product was 42.1% in one step, and the total yield was 36.1%. The purity of the product was >99.0% as determined by HPLC.

References:

CN107879962,2018,A Location in patent:Paragraph 0041; 0046

13220-33-2 Synthesis