FLUOROACETAMIDE synthesis

6synthesis methods

Product Name:FLUOROACETAMIDE
CAS Number:640-19-7
Molecular formula:C2H4FNO
Molecular Weight:77.06

Fluoroacetamide is produced by reaction of α-chloroacetamide with potassium fluoride in tetrachloroethylene at elevated temperature.

79-07-2
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640-19-7
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Yield:640-19-7 94%

Reaction Conditions:

with potassium fluoride in water at 116; for 3 h;

Steps:

10 Examples 4 to 12
General procedure: The potassium fluoride and the water are charged to a thermostated reactor equipped with a four-blade stirrer spindle. The whole mixture is brought to the desired temperature with stirring. The organic compound is added at this temperature. The medium is kept stirring at this temperature for the period of time indicated in the table below. After a return to ambient temperature, the medium is analyzed by proton and fluorine NMR. The number of equivalents is indicated in moles.

References:

RHODIA OPERATIONS;Buisine, Olivier;Dejoux, Michael US2014/148603, 2014, A1 Location in patent:Paragraph 0293-0294

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