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ChemicalBook CAS DataBase List ETHYL TRANS-4-ETHOXYCINNAMATE 97
75332-46-6

ETHYL TRANS-4-ETHOXYCINNAMATE 97 synthesis

3synthesis methods
-

Yield:75332-46-6 91%

Reaction Conditions:

Stage #1: diethoxyphosphoryl-acetic acid ethyl esterwith lithium chloride in acetonitrile at 0; for 0.333333 h;Inert atmosphere;Horner-Wadsworth-Emmons Olefination;
Stage #2: 4-ethoxybenzaldehydewith 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile at 20; for 2.2 h;Inert atmosphere;

References:

Adolfsson, Dan E.;Tyagi, Mohit;Singh, Pardeep;Deuschmann, Adrian;?dén, J?rgen;Gharibyan, Anna L.;Jayaweera, Sanduni Wasana;Lindgren, Anders E. G.;Olofsson, Anders;Almqvist, Fredrik [Journal of Organic Chemistry,2020,vol. 85,# 21,p. 14174 - 14189] Location in patent:supporting information