ChemicalBook CAS DataBase List Ethyl 3,4-dihydroxybenzoate

Ethyl 3,4-dihydroxybenzoate synthesis

9synthesis methods

Product Name:Ethyl 3,4-dihydroxybenzoate
CAS Number:3943-89-3
Molecular formula:C9H10O4
Molecular Weight:182.17

Ethyl 3,4-dihydroxybenzoate can be used as food additives and pharmaceutical intermediates. It can be synthesized by esterification of 3,4-dihydroxybenzoic acid and absolute ethanol.

64-17-5 Synthesis

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Yield:3943-89-3 95%

Reaction Conditions:

at 0; for 0.5 h;

Steps:

Ethyl ethers of 2,4- and 3,4-dihydroxybenzoic acids (c).

General procedure: The flask containing precursor b synthesized in the previous step was cooled in an ice bath. Then, 15mL of ethanol was added gradually while maintaining the temperature at 0 °C. The reaction mixture was stirred for 30 min, and then the excess ethanol was evaporated. The precipitated residue in the flask was washed with a small quantity of cool water and dried. The crude product was then recrystallized from ethanol. Yield 95%.

References:

Gamov;Kiselev;Murekhina;Zavalishin;Aleksandriiskii;Kosterin, D.Yu. [Journal of Molecular Liquids,2021,vol. 341,art. no. 116911]