Ethanone,1-(2-amino-5-chlorophenyl)- synthesis
- Product Name:Ethanone,1-(2-amino-5-chlorophenyl)-
- CAS Number:1685-19-4
- Molecular formula:C8H8ClNO
- Molecular Weight:169.61
18640-60-3
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1685-19-4
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Yield: 88%
Reaction Conditions:
with hydrogen;platinum(IV) oxide in ethanol at 20; under 760.051 Torr; for 4.5 h;
Steps:
1.b
b) A mixture of 1-(5-chloro-2-nitrophenyl)ethanone (4.40 g, 22.05 mmol), PtO2 (40 mg) and charcoal (400 mg) in EtOH (80 mL) was rapidly stirred at RT for 4.5 h under one atmosphere of hydrogen. The reaction mixture was filtered through a pad of celite (the residues washed with CH2Cl2) and concentrated under reduced pressure. The residue was filtered through a pad of silica (eluting with CH2Cl2/PE, 4:1) to afford a pale green oil which was recrystallized from Et2O/PE to give 1-(2-amino-5-chlorophenyl)ethanone (3.30 g, 88%), as pale green crystals.
References:
Winzenberg, Kevin Norman;Meyer, Adam Gerhard;Yang, Qi;Riches, Andrew Geoffrey US2007/238700, 2007, A1 Location in patent:Page/Page column 26
539-03-7
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$10.00/5 g
1685-19-4
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150879-48-4
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$110.00/50mg
917-54-4
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$44.39/50ml
1685-19-4
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