2-Amino-5-chlorobenzophenone synthesis
- Product Name:2-Amino-5-chlorobenzophenone
- CAS Number:719-59-5
- Molecular formula:C13H10ClNO
- Molecular Weight:231.68
719-64-2
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719-59-5
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Yield:719-59-5 95.1%
Reaction Conditions:
Stage #1: 5-chloro-3-phenylanthranilwith iron in ethanol; for 0.5 h;Reflux;
Stage #2: with sulfuric acid in ethanol; for 1 h;Reflux;
Steps:
2.2
(2) Take 10.0g of intermediate (II) into a three-necked bottle.50ml ethanol, 4.8g iron powder,After refluxing for 0.5 h, 1 ml of sulfuric acid (6 mol/L) was added dropwise.After the completion of the dropwise addition, the reaction was refluxed for 1 h.After the reaction is completed, a NaOH solution is added to adjust the pH to 8,Cool down to 50 ° C, add 0.2g activated carbon,Reflux for 0.5h,Thermal filtration into the crystallization bottle, cooling and crystallization,Ethanol washing, drying to obtain intermediate (III) 9.60g, The yield is 95.1%.The melting point is 96.3-98.2 °C.
References:
CN108250091,2018,A Location in patent:Paragraph 0032; 0034; 0040
1159372-20-9
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719-59-5
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7716-88-3
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719-59-5
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