DIISOPROPYL METHYLPHOSPHONATE synthesis
- Product Name:DIISOPROPYL METHYLPHOSPHONATE
- CAS Number:1445-75-6
- Molecular formula:C7H17O3P
- Molecular Weight:180.18
116-17-6
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1445-75-6
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Yield: 100%
Reaction Conditions:
at 60 - 100; for 1 h;Inert atmosphere;
Steps:
Synthesis of diisopropyl methylphosphonate S1
Triisopropyl phosphite (264 mL, 1.15 mol) was heated at 60 C. MeI (100 mL, 41.6 mol) wasslowly dropwised at this temperature. A exothermic reaction started, and heating wasdiscontinued until there was no more refluxing. The temperature was increased slowly to 100C and kept at the temperature for 1 h. The isopropyliodide was distilled off at ordinarypressure, and then the residue was distilled in vacuo (86-87 C, 14 torr) to quantitativelyafford S1 (124 g) as a colorless oil.
References:
Jung, Sunna;Kitajima, Yoko;Ueda, Yasuyuki;Suzuki, Keisuke;Ohmori, Ken [Synlett,2016,vol. 27,# 10,art. no. ST-2016-U0051-L,p. 1521 - 1526] Location in patent:supporting information
993-13-5
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1445-75-6
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116-17-6
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74-95-3
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1660-95-3
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513-02-0
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1445-75-6
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691-96-3
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98432-80-5
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