DIETHYL 2-BROMOETHYLPHOSPHONATE synthesis
- Product Name:DIETHYL 2-BROMOETHYLPHOSPHONATE
- CAS Number:5324-30-1
- Molecular formula:C6H14BrO3P
- Molecular Weight:245.05
Yield:5324-30-1 95%
Reaction Conditions:
for 2 h;Reflux;
Steps:
1.i
1,2-dibromoethane (69 ml, 0.8 mol) was poured into a two-necked 150 mL round-bottom flask. Triethylphosphite (34.3 ml, 0.2 mol) was added under stirring and the mixture was then refluxed for 2 hours. The excess of 1,2-dibromoethane was removed by rotary evaporation under gentle warming at 60-70° C. The residue was distilled under reduced pressure (2 mmHg, 95-105° C. or 1 mmHg, 75° C.). Yield 95%.1H NMR (CDCl3), δ(ppm)=4.01 (m, 4H); 3.42 (q, 2H); 2.27 (m, 2H); 1.22 (t, 6H).31P{1H} (CDCl3): δ(ppm)=26.4.
References:
NIHON MED-PHYSICS CO., LTD. US2010/160615, 2010, A1 Location in patent:Page/Page column 9