ChemicalBook CAS DataBase List Cyclobutylamine

Cyclobutylamine synthesis

7synthesis methods

Product Name:Cyclobutylamine
CAS Number:2516-34-9
Molecular formula:C4H9N
Molecular Weight:71.12

The preparation of cyclobutylamine from cyclobutanecarboxylic acid and hydrazoic acid has been reported previously. Cyclobutylamine has also been prepared by the Hofmann-type rearrangement of cyclobutanecarboxamide. More recently it has been prepared in 82–87% overall yield from cyclobutanecarboxamide by oxidative rearrangement with lead tetraacetate or iodosobenzene diacetate.

Synthesis of cyclobutylamine

1191-95-3 Synthesis

1191-95-3
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2516-34-9
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Yield:2516-34-9 72%

Reaction Conditions:

Stage #1: cyclobutanonewith palladium 10% on activated carbon;benzylamine in toluene at 40; for 10 h;Autoclave;
Stage #2: with hydrogen in toluene at 40 - 80; under 22801.5 Torr; for 24 h;Autoclave;Reagent/catalyst;Pressure;Temperature;Solvent;

Steps:

1-3 Example 3

In a 100 ml autoclave, 10 g of cyclobutanone, 20 g of benzylamine,20 grams of toluene and 0.2 grams of palladium on carbon, heated to 40 ° C for 10 hours;Introduce hydrogen into the autoclave, and keep the pressure of hydrogen at 30atm.Continue to raise the temperature to 80 ° C and react for 24 hours. The gas chromatograph monitors the disappearance of cyclobutanone.The reaction was completed, the palladium carbon was removed by filtration, and the filtrate was rectified to collect the fraction having a boiling point of 85-86 ° C.7.2 g of cyclobutylamine were obtained with a yield of 72% and a purity of 98.0%.

References:

CN110483306,2019,A Location in patent:Paragraph 0025-0027

3721-95-7 Synthesis