![36505-84-7](/CAS/GIF/36505-84-7.gif)
Buspirone synthesis
- Product Name:Buspirone
- CAS Number:36505-84-7
- Molecular formula:C21H31N5O2
- Molecular Weight:385.5
![2-Chloropyrimidine](/CAS/20200515/GIF/1722-12-9.gif)
1722-12-9
541 suppliers
$10.00/1g
![8-Azaspiro[4.5]decane-7,9-dione, 8-[4-(1-piperazinyl)butyl]-](/CAS/20180601/GIF/80827-59-4.gif)
80827-59-4
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![Buspirone](/CAS/GIF/36505-84-7.gif)
36505-84-7
111 suppliers
$65.00/100mg
Yield:36505-84-7 90%
Reaction Conditions:
with C48H55ClN2Pd;sodium t-butanolate in 1,2-dimethoxyethane at 20; for 16 h;Inert atmosphere;Sealed tube;
Steps:
9.3 (3) Synthesis of Buspar
In a N2 environment, compound 1n (1.0mmol, 1.0equiv), compound 2n (1.2equiv), Pd-NHC-1 (5mol%), sodium tert-butoxide (1.2equiv), 4mL ethylene glycol dimethyl ether, The mouth of the bottle was sealed and stirred for 16 hours under nitrogen at room temperature. Dilute with water, extract 3 times with ethyl acetate, spin dry under reduced pressure, dry with anhydrous sodium sulfate, and obtain a white solid after silica gel column chromatography with a yield of 90% (346.8 mg).
References:
Sun Yat-sen University;Qiu Liqin;Ouyang Jiasheng CN112209972, 2021, a Location in patent:Paragraph 0195; 0202-0204
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21098-10-2
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![2-(1-Piperazinyl)pyrimidine](/CAS/GIF/20980-22-7.gif)
20980-22-7
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$5.00/1g
![Buspirone](/CAS/GIF/36505-84-7.gif)
36505-84-7
111 suppliers
$65.00/100mg
![3,3-Tetramethyleneglutarimide](/CAS/GIF/1075-89-4.gif)
1075-89-4
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$11.00/5g
![Buspirone EP Impurity B](/CAS/20180703/GIF/81461-73-6.gif)
81461-73-6
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![Buspirone](/CAS/GIF/36505-84-7.gif)
36505-84-7
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$65.00/100mg
![2-(1-Piperazinyl)pyrimidine](/CAS/GIF/20980-22-7.gif)
20980-22-7
360 suppliers
$5.00/1g
![Buspirone EP Impurity M](/CAS/GIF/80827-62-9.gif)
80827-62-9
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$80.00/50mg
![Buspirone](/CAS/GIF/36505-84-7.gif)
36505-84-7
111 suppliers
$65.00/100mg
![3,3-Tetramethyleneglutaric anhydride](/CAS/GIF/5662-95-3.gif)
5662-95-3
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$34.00/1g
![1-(2-Pyrimidinyl)-4-(4-aminobutyl)piperazine](/CAS/GIF/33386-20-8.gif)
33386-20-8
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$505.64/5MG
![Buspirone](/CAS/GIF/36505-84-7.gif)
36505-84-7
111 suppliers
$65.00/100mg