Yield:-

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide at 20 - 45; for 20 h;Product distribution / selectivity;

Steps:

19

Example 19; [00087] 8.0 g of saturated alcohol (V) were dissolved in THF or Toluene (40 ml). A catalytic amount of DMF (0.3 ml) was added to the solution. Thionyl Chloride (SOCl₂) (3.2 ml) was added drop-wise at room temperature. The reaction mixture was heated to 45⁰C for 20 hours. The solvents and traces OfSOCl₂ were evaporated under reduced pressure to give 9.5 g of the crude chloride derivative (VI). The crude material may be purified by vacuum distillation (80-87°C/2mmHg).

References:

WO2006/125026,2006,A2 Location in patent:Page/Page column 28