ChemicalBook CAS DataBase List arecoline

arecoline synthesis

8synthesis methods

Product Name:arecoline
CAS Number:63-75-2
Molecular formula:C8H13NO2
Molecular Weight:155.19

300-08-3
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Yield:63-75-2 100%

Reaction Conditions:

with potassium carbonate in dichloromethane;water at 20; for 0.5 h;

Steps:

Methyl 1 -methyl- 1,2,5,6-tetrahydropyridine-3-carboxylate.K₂C0₃ (50 g; 361 .78 mmol) was added to a solution of methyl 1 -methyl-1 ,2,5,6- tetrahydropyridine-3-carboxylate hydrobromide (50 g; 21 1 .77 mmol) in H₂0 (50 ml) and DCM (250 ml), and stirred at RT for 30 mins. The organic layer was separated, washed with brine, dried over MgS0₄, filtered and concentrated to provide the desired intermediate (34 g, quantitative yield).

References:

WO2012/16001,2012,A1 Location in patent:Page/Page column 50

59-67-6 Synthesis