8-METHYL-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE synthesis
- Product Name:8-METHYL-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
- CAS Number:86499-66-3
- Molecular formula:C11H13NO
- Molecular Weight:175.23
53078-85-6
192 suppliers
$6.00/1g
86499-66-3
8 suppliers
inquiry
Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: acetic anhydride / dichloromethane / 2 h / 20 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
2.3: 2 h / -78 °C / Inert atmosphere
3.1: potassium hydroxide / 1,4-dioxane; water / Inert atmosphere; Reflux
4.1: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 1.5 h / 0 - 20 °C / Inert atmosphere
5.1: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / toluene / 16 h / 120 °C / Schlenk technique; Inert atmosphere; Sealed tube
References:
Mazumdar, Wrickban;Jana, Navendu;Thurman, Bryant T.;Wink, Donald J.;Driver, Tom G. [Journal of the American Chemical Society,2017,vol. 139,# 14,p. 5031 - 5034]
5326-39-6
153 suppliers
$6.00/1g
86499-66-3
8 suppliers
inquiry
22009-37-6
130 suppliers
$10.00/250mg
86499-66-3
8 suppliers
inquiry